Because portable versions run inside a virtual layer, they are notoriously buggy. You may experience:
While the idea is tempting, downloading an from an unverified source carries significant risks. adobe indesign cs6 portable portable
Adobe does not authorize "portable" versions of their software. Using them is a violation of Terms of Service and intellectual property laws. Because portable versions run inside a virtual layer,
How Adobe Is Giving Design A Bad Name | by Allen - Prototypr make your entire Windows portable.
Instead of making InDesign portable, make your entire Windows portable.