In addition to her film work, Manisha has been recognized for her contributions to social causes. She has been involved with various charitable organizations and has supported causes like cancer awareness and education.

Manisha made her film debut in 1989 with the Nepali film "Panchi," but it was her Bollywood debut in 1991 with the film "Saajan" that brought her widespread recognition. Her performance in the film earned her a nomination for the Filmfare Award for Best Female Debut.