If the error persists across multiple missions, your hard drive might have bad sectors.
Lowering Texture Quality to "Manual" or reducing Specular Map Resolution from "Extra" to "High" can sometimes bypass memory-related crashes during mission loading.
For the uninitiated, few things ruin a nostalgia trip faster than a hard crash. You’re playing the eighth mission, "Homecoming"—where you defend the U.S. carrier group from orbital bombardment—when the screen freezes. A harsh buzz emits from the speakers. Then, the dreaded black box appears: "Fatal Error: Disc Read Error 'Homecoming'."
Below is a comprehensive guide to resolving this error across PC and console platforms. Understanding the "Homecoming" Error